James "Jimmy" Chance is a clueless 24-year-old who impregnates a serial killer during a one-night-stand. Earning custody of his daughter after the mother is sentenced to death, Jimmy relies on his oddball but well-intentioned family for support in raising the child.
Num hospital de Chicago, a equipe médica luta todos os dias para superar seus interesses e problemas pessoais e desvios de ética para fazer o que permnece como a coisa mais importante: salvar vidas.